Over the past 30 years, cure rates for childhood cancers have improved dramatically. Today, approximately 70% of children diagnosed with malignancies survive. Although there have been notable successes in treatment of many types of pediatric cancers, there remain groups of patients for whom current therapy is ineffective.

Despite dose intensive chemotherapy, surgery, and/or radiation therapy, children with certain malignancies frequently battle recurrent, refractory disease that does not respond to treatments currently available. New therapies are desperately needed.

The Arizona Children’s Therapeutic and Investigational Oncology Network (ACTION) is an important step forward for children in the Southwest who suffer from difficult-to-treat malignancies. Through a cooperative effort by pediatric oncologists based in Phoenix and in Tucson, patients with refractory and relapsed malignancies will be enrolled in clinical trials and treated with the most promising new agents available.

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